Need your advice about layout, when there is 60v in the circuit

I have never laid out a PCB with potential higher than 24 volts, so I'm wary that must some "trivals & tricks" I will miss. so please give me your advice what should be paid attention when supply is 50v or 60v (and the current current may be 10A from the 60v supply.) for example special space between lines, cascade structure ....

thanks.

Hello
Is this D.C or A.C?

Keep in mind that, as a rule of thumb, air can withstand ca. 1 kV/mm potential before arcing over. A solder mask provides additional isolation, so practically you won't have to increase the clearance too much for a 60 V board. However, higher voltages lead to stronger electrostatic interference with adjacent traces, so unless your 60V lines are DC, avoid running them close to any other sensitive traces or components.

Regarding the current, consider that any trace, regardless its width, will have a certain impedance and thereby cause a voltage drop. If the current or impedance is too high, the trace may heat up too much and in extreme cases result in a fire hazard or a burnout (the copper gets so hot it evaporates, severing the connection).
As a rule of thumb, I set the width to 1 mm/A/oz. For example, to run a 10 A current over a board, use a 10 mm trace on a 1 oz (35 µm copper thickness) board and 5 mm trace on a 2 oz (70 µm) board.

ArticCynda, Thanks for you kindly reply. That is really helpful to me.

Hi, arouse1973, the current source from the supply(60V) is modulated by 2KHz signal. so it is AC.

Just because it's modulated doesn't mean it's A.C. If the output voltage doesn't go negative or the current doesn't change direction then it's not A.C. The reason I ask is that the regulation LVD asks what the voltage is because AC is expressed in RMS. But for you your lucky you are 15 Volts under the 75 Volts D.C limit. ArticCynda gave you some other good advice to check out. In addition to this you need to consider creepage distances. But for your design with a coated PCB a minimum gap 0.1 mm -0.2 mm should be ok. If you heed the advice from ArticCynda then I think you would naturally have gaps greater than 0.1 mm - 0.2 mm anyway.
Thanks
Adam